This course will focus on computational neuroscience from the combined perspective of data collection, data analysis, and computational modeling. These issues will be explored through lectures as well as Matlab-based tutorials and exercises. The course requires no prior knowledge of computer programming and a limited math background, but familiarity with some basic statistical concepts will be assumed. The course is an ideal preparation for students interested in participating in a more independent research experience in one of the labs on campus.

This course will focus on computational neuroscience from the combined perspective of data collection, data analysis, and computational modeling. These issues will be explored through lectures as well as Matlab-based tutorials and exercises. The course requires no prior knowledge of computer programming and a limited math background, but familiarity with some basic statistical concepts will be assumed. The course is an ideal preparation for students interested in participating in a more independent research experience in one of the labs on campus.

This seminar will focus on the significant role of animal models in the investigation of the pathophysiology of a variety of human neuropsychiatric disorders as well as in the development of treatments for these disorders. The course will focus on the use of genetically modified mice in the investigation of Autistic Spectrum Disorders (ASD), anxiety and affective disorders, schizophrenia and obsessive-compulsive disorder (OCD), with an emphasis on the limitations of such models. Class time will consist of short lectures and open discussions via student-led presentations. Emphasis will be placed on the critical analysis of primary literature.

In a world where humans can't seem to agree on much of anything, there is one thing that still unites us: we love music. Why should abstract sequences of sounds give us such strong emotional reactions? Why indeed should they give us any emotional reaction at all? On every continent, today and throughout history, there is not a single human culture that has ever been described that does not make music. Within cultures, music is so ubiquitous that we actually have clinical terms (amusia and musical anhedonia) to describe people who don't understand or don't enjoy music. And yet, despite this ubiquity, the evolutionary origin and purpose of music remains unknown. Not only do people everywhere make music - they do so in fundamentally similar ways. All over the world people divide rhythm into twos and threes; all over the world people divide the frequency spectrum logarithmically, in octaves; with a very few exceptions, we divide octaves into no more than 12 steps, and we use subsets of 5-7 of these tones at a time. Not only that, but many cultures seem to have independently arrived at the same sets of 5-7 notes. These are probably not coincidences. If not coincidence, then what? In this course we look for explanations to these and other questions about music by looking at something that humans all over the globe have in common: the brain. Using readings from the primary literature and classic texts, supplemented with software exercises and analysis, we will see how many of the age-old mysteries and questions of music can be either answered or in some cases amplified by a consideration of brain mechanisms. Thinking about music in the context of brain function also provides a biological and evolutionary rationale not just for why music is the way it is, but why it should exist at all. More broadly, this course is an example of what can (and cannot) be accomplished by addressing aesthetic and philosophical questions as scientific and empirical ones. Prerequisite: NRSC 1110 and prior musical instruction, any instrument.

Both clinical observations and popular culture support the idea that food might have addictive properties. Similar to the narrative for addictive drugs,individuals and the media use terms like "food addict" and "chocoholic", and refer to cravings, symptoms of withdrawal, and escalating patterns of eating that might be viewed as evidence of tolerance. The class will discuss chocolate and coffee as examples of so-called "addictive" food and compare their effects and mechanisms with those of alcohol and nicotine, two substances with well-characterzed addictive properties. Furthermore, we will discuss why some forms of overeating are thought to reflect an addictive behavior. Considering the social dimension of alcohol,coffee, and tobacco consumption and the fact that large numbers of the population consume them together, we will also discuss the possible interactive effects of combinationsof these psychoactive substances on mood and disease state. At the end of the course the student will become familiar with the diagnostic criteria for substance dependence, the anatomy and physiology of the brain circuits involvedin reward processing and drug depencence, and the neurotransmitter systems involved.

Microtubules are dynamic cytoskeletal filaments that are crucial to the structure and function of neurons. From providing the scaffolding for the unique architecture of neurons, to guiding intracellular trafficking, to supporting neuronal migration and connectivity, microtubules are important for a variety of neuronal roles. Consequentially, the dysfunction of microtubules and microtubule-associated-proteins is associated with a number of nervous system disorders. This seminar will explore the role of microtubules in a number of neurobiological diseases and disorders including Neurodevelopmental disorders (ex. Fragile X, Lissencephaly), Neurodegenerative Disorders (ex. Alzheimer's and the Tauopathies, Hereditary Spastic Paraplegia), Psychiatric Disorders (Ex. Schizophrenia and Mood disorders), and also in Traumatic Brain Injury. We will use readings from the primary literature as a basis for lectures, student presentations, and papers.

This course will investigate neural processing at the systems level. Principles of how brains encode information will be explored in both sensory (e.g. visual, auditory, social, etc.) and motor systems. Neural encoding strategies will be discussed in relation to the specific behavioral needs of the animal. Examples will be drawn from a variety of different model systems.

A laboratory course designed to familiarize the student with the fundamental gross and histological organization of the brain. The mammalian brain will be dissected and its microscopic anatomy examined using standard slide sets. Comparative brain material will be introduced, where appropriate, to demonstrate basic structural-functional correlations.

The study of the neural systems that underlie human perception, memory and language; and of the pathological syndromes that result from damage to these systems.

This course will introduce students to the molecular, cellular, and systems-level mechanisms that underlie how experiences are acquired, stored and retrieved in the central nervous system. The interdisciplinary nature of this topic reflects the diverse, historical approaches used to understand how organisms, from aplysia to humans, learn and remember. To scaffold our discussions, we will explore how key methodological advances in the field of neuroscience, produced a paradigm-shift in our understanding of the neurobiology of learning and memory. The course is primarily lecture-based with opportunities for students to engage actively with course material.