NRSC4413 - Cellular Structure and Neurological Disorders

Microtubules are dynamic cytoskeletal filaments that are crucial to the structure and function of neurons. From providing the scaffolding for the unique architecture of neurons, to guiding intracellular trafficking, to supporting neuronal migration and connectivity, microtubules are important for a variety of neuronal roles. Consequentially, the dysfunction of microtubules and microtubule-associated-proteins is associated with a number of nervous system disorders. This seminar will explore the role of microtubules in a number of neurobiological diseases and disorders including Neurodevelopmental disorders (ex. Fragile X, Lissencephaly), Neurodegenerative Disorders (ex. Alzheimer's and the Tauopathies, Hereditary Spastic Paraplegia), Psychiatric Disorders (Ex. Schizophrenia and Mood disorders), and also in Traumatic Brain Injury. We will use readings from the primary literature as a basis for lectures, student presentations, and papers.